Endocrine Abstracts

Acromegalic osteopathy is an emerging complication of chronic GH excess characterized by increase in bone turnover, deterioration in bone microarchitecture and high risk of vertebral fractures (VFs). Medical therapies may exert direct effects on peripheral targets leading to improvement of clinical outcomes regardless of biochemical control of acromegaly. In this longitudinal study, we compared the effects pegvisomant (PegV) and somatostatin receptor ligands (SRLs) on VF risk ...

Introduction: Differentiated thyroid cancer (DTC) is one of the most frequent forms of malignancy. Because of its favourable outcome and low mortality rates, identifying prognostic factors has been a challenge. Several risk stratification systems have been developed. Most of them include demographic and tumour specific features, as well as extrathyroidal extension. Our objective was to compare clinical characteristics between DTC patients with and without remission.<p clas...

Berardinelli-Seip syndrome is an autosomal recessive disorder characterized by generalized lipoatrophy, extreme insulin resistance with dyslipidaemia in childhood and development of diabetes and hepatic steatosis in adolescence. The metabolic derangements can be severe and lead to substantial comorbidities, including acute pancreatitis, hepatic cirrhosis, and premature cardiovascular disease. Other manifestations can include polycystic ovarian syndrome, acanthosis nigricans, a...

Pasireotide, a multireceptor-targeted somatostatin analogue, was approved for the treatment of acromegaly, after being studied in two large, randomised, multi-center clinical trials. We reported the history of a 76 years old man affected by acromegaly, treated with Pasireotide long acting release (LAR) as first line therapy. Acromegaly was diagnosed in 2009, as the result of endocrinological investigation suggested by altered facial appearance and macroglossia. Hormonal assays...

The work-up of Differentiated Thyroid Cancer (DTC) patients includes thyroid surgery, thyroid remnant ablation (TRA) with 131-radioiodine and long life follow-up. 131I-post therapy whole body scan (pT-WBS) and thyroglobulin (Tg) are used in identifying metastatic patients. Some authors suggested to use post-surgical Tg (ps-Tg) values in deciding for or against TRA. The aim of our study was to verify the sensitivity and PPV of 131I-pT-WBS compared to serum Tg levels in detectin...

Introduction: Bone and energy metabolisms are deeply related determining a two-way street aimed in regulating the energy utilization [1]. Mountain ultra-marathons are peculiar aerobic performances hardly proving whole body homeostasis [2]. In this study we aimed at investigating and characterizing the metabolic profile (hormones involved in energy metabolism), the metabolic inflammation profile (adipokines), the bone metabolism (bone turnover markers), and their integration (m...

Introduction: Although underlying mechanisms are largely unknown, bone metabolism is regulated by specific microRNAs and changes in their expression are associated with metabolic bone disorders. Exercise is a determinant of bone metabolism; however, different training protocols differently affect bone. Little is known about the effects of exercise on bone-specific miRNA expression.We studied the effect of a 8-week high-intensity training protocol on circ...

Introduction: New treatments of diabetes, such as dapagliflozin, improve global metabolic status beyond glycemic control.Aim: To evaluate tolerance to dapagliflozin and its effects on metabolic control in type 2 diabetes and obese patients attended in endocrinology offices.Material and method: A prospective study of patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and analytical data were evaluated ...

Background: Endothelial dysfunction leads to cardiovascular complications in type 2 diabetes mellitus (T2DM), through a reduction of nitric oxide (NO)-mediated relaxation. Phosphodiesterase-5 inhibitors (PDE5i) have hemodynamic effects, improving NO levels.Aim: To investigate if long term, chronic treatment with the PDE5i Vardenafil improves systemic endothelial function in men with T2DM.Methods: A longitudinal, prospective, invest...

Purpose: MicroRNAs (miRNAs) are a fundamental component of gene regulation mechanisms. Presently, altered miRNA patterns of expression have been documented in different human cancers, and they may explain the distinct behavior of pituitary adenomas (PA) and the differences between subtypes. miR-375 can target among other genes to IGF1 receptor (IGF1R) and participes in reprogramming cancer cell metabolism. The aim of this study was to assess the miR-375 role on pathogenesis of...